at what stage of the cell cycle is the cyclin component of mpf destroyed?

The cyclin component of MPF is destroyed toward the end of M phase, specifically as the cell passes through anaphase in late mitosis.

Quick Scoop

• MPF (Maturation-Promoting Factor) is a complex of Cdk1 and a mitotic cyclin (often cyclin B) that pushes the cell from G2 into M phase.

• As mitosis progresses, MPF not only drives M-phase events but also helps trigger its own inactivation by activating the anaphase-promoting complex/cyclosome (APC/C).

• APC/C tags the cyclin component of MPF for degradation by ubiquitination beginning at the metaphase–anaphase transition and continuing through late M phase, so the cyclin is effectively destroyed in late M phase.

In one line

• The cyclin component of MPF is destroyed in late M phase, as the cell goes through anaphase and exits mitosis.

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