cast of best medicine
“Best Medicine” is a 2026 Fox TV dramedy (a remake of Doc Martin) led by Josh Charles as a brilliant but abrasive small‑town doctor.
Main cast (core roles)
- Josh Charles as Dr. Martin Best , a talented Boston surgeon who returns to the coastal town where he spent his childhood summers and struggles with bedside manner and hidden phobias.
- Abigail Spencer as Louisa (listed as Louisa Gavin/Glasson in early materials), a warm local schoolteacher who clashes with Martin but is also drawn to him.
- Josh Segarra as Sheriff Mark Mylow , the charming lawman who knows everyone in town and ends up in a love‑triangle dynamic with Martin and Louisa.
- Cree as Elaine (Elaine Denton/Denham), Martin’s administrative assistant, who is also trying to become an online creator.
- Annie Potts as Aunt Sarah/Aunt Joan , Martin’s aunt and a tough local “lobster woman,” giving him both family grounding and comic friction.
Key recurring and supporting players
- Alexandria Benford as Belinda , appearing in multiple episodes in 2026.
- Patch Darragh as Glendon Ross , a town local with recurring ties to Martin’s practice.
- Ellen Boscov as “Coffee Karla,” a regular presence around town’s social hub.
- Leah Janae Thomas as Amelia , another recurring local character.
- Michael Potts as Gilbert Carlisle , a notable supporting role in the first season.
Doc Martin universe connections
- Martin Clunes (the original Doc Martin star) appears as Dr. Robert Best , Martin’s father, creating a direct bridge between the British series and this adaptation.
- Didi Conn as Councilwoman Geneva Potter , Clea Lewis as Pharmacist Sally Mylow , Stephen Spinella as Greg Garrison , Jason Veasey as George Brady , and John DiMaggio as Burt Large , all help round out the quirky coastal community.
At‑a‑glance cast table
| Actor | Character | Notes |
|---|---|---|
| Josh Charles | Dr. Martin Best | Lead; big‑city surgeon turned small‑town doctor. | [7][1]
| Abigail Spencer | Louisa (Gavin/Glasson) | Local schoolteacher; main romantic foil. | [3][1][7]
| Josh Segarra | Sheriff Mark Mylow | Town sheriff; part of a love triangle. | [3][1][7]
| Cree | Elaine (Denton/Denham) | Administrative assistant and aspiring influencer. | [1][5]
| Annie Potts | Aunt Sarah / Aunt Joan | Martin’s aunt; local lobster woman. | [1][5]
| Martin Clunes | Dr. Robert Best | Martin’s father; cameo from original Doc Martin star. | [1][5]
| Didi Conn | Geneva Potter | Town councilwoman. | [9]
| Clea Lewis | Sally Mylow | Pharmacist; linked to Sheriff Mylow. | [9]
| Stephen Spinella | Greg Garrison | Proprietor of local business “Saltyreeze.” | [9]
| Jason Veasey | George Brady | Co‑proprietor of Saltyreeze. | [9]
| John DiMaggio | Burt Large | Handyman around town. | [9]