Quick Scoop

Cholestasis of pregnancy, also called intrahepatic cholestasis of pregnancy, is **uncommon** overall and is generally described as the most common liver condition specific to pregnancy.

How common it is

• In many populations, it affects roughly 1 in 140 to 1 in 1,000 pregnancies , depending on the region and risk factors.

• It is more common in some groups and can be more frequent with a prior history, multiple pregnancy, or certain liver conditions.

• If someone had it before, recurrence can be high: Mayo Clinic notes about 60% to 70% recurrence overall, and up to 90% in severe cases.

Why the rate varies

Different studies and clinics report different numbers because the diagnosis depends on how bile acids are tested, local awareness, and the population being studied. Some recent research also suggests genetic and ancestry-related factors may influence risk.

When to get checked

The classic symptom is intense itching , often in the third trimester, especially on the palms and soles, sometimes without a rash. Because it can affect the baby’s risks, itching in pregnancy should be discussed with a clinician promptly.

Bottom line

It is not common, but it is common enough that doctors take it seriously because of the pregnancy risks tied to it.