she is really .....about the news
She is really upset about the news. That’s the most natural and commonly used word to complete the sentence:
she is really upset about the news
Other good options, depending on the feeling you want, could be:
- she is really shocked about the news
- she is really anxious about the news
- she is really worried about the news
But if you need just one best fit for everyday English, “upset” is the strongest choice.