what are the worst side effects of prednisone

Prednisone can cause some serious side effects , especially at higher doses or when used for longer periods. The biggest concerns are infection risk, high blood sugar, high blood pressure, mood changes, osteoporosis/bone fractures, eye problems, stomach ulcers, and adrenal suppression.

Worst side effects

The side effects people usually worry about most are:

• Infections or getting sick more easily.

• Mood and behavior changes , including agitation, irritability, depression, or insomnia.

• High blood sugar or triggering/worsening diabetes.

• Bone thinning and fractures with longer use.

• Eye problems like cataracts or glaucoma.

• Stomach ulcers or severe stomach pain.

• Fluid retention, swelling, and high blood pressure.

Get urgent help if

Seek medical help right away if you have:

• Trouble breathing, chest pain, or a fast/irregular heartbeat.

• Severe mood changes, confusion, or suicidal thoughts.

• Vision changes.

• Black stools, vomiting blood, or severe abdominal pain.

• Signs of infection such as fever, sore throat, or cough that is worsening.

What raises the risk

The risk is higher with larger doses , longer treatment , and in people who already have diabetes, high blood pressure, bone loss, or eye disease.

Quick note

If you tell me your dose , how long you’ve been taking it , and what symptoms you’re noticing , I can help you judge whether it sounds like a common side effect or something that needs urgent care.