Quick Scoop: What Is Simparica Trio?

Simparica Trio is a prescription monthly chewable for dogs that helps protect against heartworm disease, fleas, ticks, roundworms, and hookworms. It contains three active ingredients: sarolaner, moxidectin, and pyrantel pamoate.

What It Does

• Prevents heartworm disease.

• Kills adult fleas and helps prevent flea infestations.

• Treats and controls several tick species.

• Treats and controls roundworms and hookworms.

How It’s Taken

It is given once a month as a chewable tablet, and it requires a veterinarian’s prescription. Zoetis describes it as safe for puppies as young as 8 weeks old and weighing at least 2.8 pounds.

Recent Context

In 2025, the FDA approved a new indication for Simparica Trio to help prevent flea tapeworm infections by killing vector fleas in treated dogs. Zoetis also reported that the product has been used in more than 15 million dogs over its five years on the market.

Things To Know

• It is meant for dogs, not cats or people.

• Because it is prescription-only, a vet should confirm the right dose for your dog.

• Online discussions often describe it as convenient and broad-coverage, but some owners note cost concerns.

If you want, I can also explain side effects, how it compares with NexGard or Heartgard, or whether it’s a good option for your dog.