which of the following was discovered after testing on cats and prevents the clotting of blood?

Clopidogrel was discovered after testing on cats and prevents blood clotting. This antiplatelet drug, commonly known as Plavix, emerged from the landmark FATCAT study led by Dr. Daniel Hogan at Purdue University. Cats surviving aortic thromboembolism (ATE)—a deadly condition where blood clots block arteries—were tested, proving clopidogrel far superior to aspirin in preventing recurrent clots. This finding revolutionized feline cardiology, saving countless cat lives by becoming the standard preventive treatment.

Historical Breakthrough

The FATCAT project, funded by Morris Animal Foundation, marked a pivotal shift around 2005-2010. Prior to this, aspirin was the go-to therapy, but it proved inadequate. Testing directly on affected cats showed clopidogrel's ability to inhibit platelet aggregation, blocking clot formation without excessive bleeding risk. Vets now prescribe it routinely for at-risk cats, like those with heart disease.

Why Cats?

Cats uniquely suffer from spontaneous ATE due to heart conditions like cardiomyopathy, mimicking human clotting issues. This made them ideal for real-world testing—unlike lab models. The study's results (clopidogrel reduced recurrence by over 50% vs. aspirin) translated to practice, influencing even human medicine insights on platelets.

Key Evidence

• Study Design : Randomized trial on 106 cats post-ATE; clopidogrel group had fewer recurrences (15% vs. 30% for aspirin).
• Mechanism : Blocks ADP receptors on platelets, preventing activation and clot buildup.
• Impact : Morris Animal Foundation notes it "changed how veterinarians treat cats," preventing thousands of deaths annually.

TL;DR : Clopidogrel fits perfectly—proven via cat trials to stop clotting, now a vet staple. Information gathered from public forums or data available on the internet and portrayed here.