which type of transport is impacted in cystic fibrosis?

The type of transport primarily impacted in cystic fibrosis is ion transport across epithelial cell membranes , specifically chloride (Cl⁻) and bicarbonate (HCO₃⁻) secretion via the CFTR channel.

Because CFTR is a chloride and bicarbonate channel on the apical (luminal) surface of epithelial cells, its dysfunction leads to:

• Reduced Cl⁻ secretion and altered Na⁺ movement
• Impaired HCO₃⁻ transport, which changes fluid pH and mucus properties
• Secondary impairment of mucociliary transport in the airways because mucus becomes thick and hard to clear.

In exam-style terms, the answer is:

Epithelial ion transport (Cl⁻ and HCO₃⁻ transport via CFTR) is affected in cystic fibrosis.

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