who did michigan state lose to

Michigan State’s most recent notable football loss in the 2025 season was to USC, 45–31, in Los Angeles.

Quick answer

• In the 2025 season, Michigan State lost to USC 45–31 in a late-night road game at the Los Angeles Memorial Coliseum.

• Earlier in the 2024 season, they also lost to Michigan 24–17 in a rivalry matchup, which drew a lot of fan reaction on MSU forums.

Recent key losses

• USC (2025 season)
  • Final score: USC 45, Michigan State 31.

* MSU fell behind by as many as 21 points but closed the gap to 7 before USC pulled away again in the fourth quarter.

* Quarterback Aidan Chiles threw three touchdown passes, but the defense gave up 523 total yards, including 289 rushing yards.

• Michigan (2024 season)
  • Final score: Michigan 24, Michigan State 17.

* The game sparked a heated post‑game discussion among fans on MSU‑related forums, with many blaming mistakes and lost opportunities.

If you meant another sport or date

“Who did Michigan State lose to” can refer to different seasons, weeks, or sports (basketball, football, etc.). The latest high‑profile answer in football is USC (45–31), but if you share:

• The sport (football, men’s basketball, etc.)
• The season or date (e.g., “this week,” “NCAA tournament 2024”)

then a more precise, game‑specific answer can be given.