who did south carolina lose to

South Carolina’s most recent high-profile loss was a 28–14 defeat to Clemson in the Palmetto Bowl at the end of the 2025 football regular season.

Quick context

• The game was played at Williams-Brice Stadium in Columbia and capped a 4–8 season for South Carolina football.

• Clemson has now beaten South Carolina multiple times in a row in Columbia, adding to fans’ frustration.

So if you’re asking “who did South Carolina lose to?” in the sense of their latest big, talked‑about loss, the answer is Clemson , 28–14, in the 2025 Palmetto Bowl.