You technically can drink alcohol while on Prozac, but most medical sources strongly advise avoiding it because the combo can worsen side effects and your mental health symptoms.

Quick Scoop

  • Mixing Prozac (fluoxetine) and alcohol is not recommended , even in small amounts.
  • Alcohol can make Prozac’s side effects stronger: more drowsiness, dizziness, poor coordination, and feeling “extra drunk” on fewer drinks.
  • The combo can also worsen depression and anxiety and may make Prozac work less effectively over time.
  • Because Prozac stays in your system for weeks, “skipping a dose to drink” does not make it safe.
  • The safest move is to talk with your prescriber before drinking at all on Prozac, especially if you have a history of low mood, anxiety, or alcohol problems.

If you’re already drinking on Prozac and feel more depressed, anxious, or unlike yourself, that is a good reason to reach out to your doctor or a mental health professional as soon as you can.