“Best Medicine” is a 2026 Fox TV dramedy (a remake of Doc Martin) led by Josh Charles as a brilliant but abrasive small‑town doctor.

Main cast (core roles)

  • Josh Charles as Dr. Martin Best , a talented Boston surgeon who returns to the coastal town where he spent his childhood summers and struggles with bedside manner and hidden phobias.
  • Abigail Spencer as Louisa (listed as Louisa Gavin/Glasson in early materials), a warm local schoolteacher who clashes with Martin but is also drawn to him.
  • Josh Segarra as Sheriff Mark Mylow , the charming lawman who knows everyone in town and ends up in a love‑triangle dynamic with Martin and Louisa.
  • Cree as Elaine (Elaine Denton/Denham), Martin’s administrative assistant, who is also trying to become an online creator.
  • Annie Potts as Aunt Sarah/Aunt Joan , Martin’s aunt and a tough local “lobster woman,” giving him both family grounding and comic friction.

Key recurring and supporting players

  • Alexandria Benford as Belinda , appearing in multiple episodes in 2026.
  • Patch Darragh as Glendon Ross , a town local with recurring ties to Martin’s practice.
  • Ellen Boscov as “Coffee Karla,” a regular presence around town’s social hub.
  • Leah Janae Thomas as Amelia , another recurring local character.
  • Michael Potts as Gilbert Carlisle , a notable supporting role in the first season.

Doc Martin universe connections

  • Martin Clunes (the original Doc Martin star) appears as Dr. Robert Best , Martin’s father, creating a direct bridge between the British series and this adaptation.
  • Didi Conn as Councilwoman Geneva Potter , Clea Lewis as Pharmacist Sally Mylow , Stephen Spinella as Greg Garrison , Jason Veasey as George Brady , and John DiMaggio as Burt Large , all help round out the quirky coastal community.

At‑a‑glance cast table

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Actor Character Notes
Josh Charles Dr. Martin Best Lead; big‑city surgeon turned small‑town doctor.
Abigail Spencer Louisa (Gavin/Glasson) Local schoolteacher; main romantic foil.
Josh Segarra Sheriff Mark Mylow Town sheriff; part of a love triangle.
Cree Elaine (Denton/Denham) Administrative assistant and aspiring influencer.
Annie Potts Aunt Sarah / Aunt Joan Martin’s aunt; local lobster woman.
Martin Clunes Dr. Robert Best Martin’s father; cameo from original Doc Martin star.
Didi Conn Geneva Potter Town councilwoman.
Clea Lewis Sally Mylow Pharmacist; linked to Sheriff Mylow.
Stephen Spinella Greg Garrison Proprietor of local business “Saltyreeze.”
Jason Veasey George Brady Co‑proprietor of Saltyreeze.
John DiMaggio Burt Large Handyman around town.
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