The core cast of Whose Line Is It Anyway? depends on which version you mean: the original UK series, the classic US run with Drew Carey, or the revived US version with Aisha Tyler as host.

Main US TV casts (quick scoop)

Drew Carey era (US, 1998–2007)

The best‑known US version on ABC/ABC Family had:

  • Drew Carey – host of all episodes in this run.
  • Ryan Stiles – main performer in every episode.
  • Colin Mochrie – main performer in every episode.
  • Wayne Brady – frequent core performer (became a breakout star from the show).

Very frequent recurring improvisers included:

  • Greg Proops
  • Brad Sherwood
  • Chip (Charles) Esten
  • Jeff Davis
  • Kathy Greenwood
  • Denny Siegel
  • Josie Lawrence (also a mainstay of the UK version)

These performers rotated so each episode typically had Ryan, Colin, Wayne plus one guest performer (like Greg Proops or Brad Sherwood).

Aisha Tyler era (US CW revival, 2013–2024)

The later CW revival kept the improv “big three” and added a new host:

  • Aisha Tyler – host and sometimes participant across more than 200 episodes (2013–2024).
  • Ryan Stiles – regular performer.
  • Colin Mochrie – regular performer.
  • Wayne Brady – regular performer.

Common guest/fourth‑chair performers on the revival included:

  • Gary Anthony Williams
  • Jeff Davis
  • Greg Proops
  • Heather Anne Campbell
  • Keegan‑Michael Key
  • Jonathan Mangum
  • Nyima Funk
  • Brad Sherwood
  • Charles “Chip” Esten

Episodes also regularly featured celebrity guests (e.g., Lauren Cohan, Maggie Q, Jordin Sparks) who would jump into specific games rather than perform the whole show.

Original UK TV cast (Channel 4, late 1980s–1990s)

The show started in the UK, where the host and rotation were slightly different:

  • Clive Anderson – host/presenter.
  • Ryan Stiles – became a regular from series 2 onward.
  • Colin Mochrie – regular from series 3 onward.
  • Tony Slattery – prominent early‑series performer.
  • Greg Proops – frequent regular.

Other recurring UK‑era improvisers included Stephen Fry, Josie Lawrence, Niall Ashdown, and Chip Esten, among many others.

Handy cast snapshot (US & UK)

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Version Host Core performers Notable recurring guests
US (1998–2007) Drew Carey Ryan Stiles, Colin Mochrie, Wayne Brady Greg Proops, Brad Sherwood, Chip Esten, Jeff Davis, Kathy Greenwood, Denny Siegel
US revival (2013–2024) Aisha Tyler Ryan Stiles, Colin Mochrie, Wayne Brady Gary Anthony Williams, Heather Anne Campbell, Keegan‑Michael Key, Jonathan Mangum, Nyima Funk, Brad Sherwood, Greg Proops, Chip Esten
UK (C4 series) Clive Anderson Ryan Stiles, Colin Mochrie, Tony Slattery, Greg Proops, Josie Lawrence (varied by series) Stephen Fry, Caroline Quentin, Niall Ashdown, Chip Esten, Wayne Brady (later appearance)

Mini context: “latest news” feel

  • The CW revival ran through 2024 with Aisha Tyler hosting and the long‑time trio still front and center, so when people ask about the cast of Whose Line Is It Anyway , they usually mean Aisha, Ryan, Colin, and Wayne.
  • Online discussions and clips still center heavily on the classic ABC era with Drew Carey plus Ryan, Colin, and Wayne, so those four remain the “iconic” lineup in fan forums.

TL;DR:
If you just want the names most fans mean by “cast of Whose Line Is It Anyway,” it’s Drew Carey (host of the original US run) or Aisha Tyler (host of the revival) plus the improv trio Ryan Stiles, Colin Mochrie, and Wayne Brady, with Greg Proops, Brad Sherwood, Chip Esten, Jeff Davis, and others rotating through the fourth chair over the years.

Information gathered from public forums or data available on the internet and portrayed here.