The crossword answer to “from which a plane takes off” is usually “runway” (6 letters). If your puzzle needs a different letter count, other common answers based on similar clues are:

  • “airport” (7 letters) – for clues like “place where planes take off and land”
  • “airstrip” (8 letters) – often used for “strip where planes take off and land”

If you tell me how many letters you need and any letters you already have, I can narrow it down further.