Use prayer restoration gear and passive restores to stay sustainable on vyres in RS3. The most commonly mentioned setup is a Demon horn necklace with bones being buried automatically by a bonecrusher, plus prayer- sustain options like a prayer regen aura or Bunyip/other familiar support if needed.

Practical ways to sustain prayer

  • Demon horn necklace + bonecrusher : buried bones restore prayer automatically, which can make prayer upkeep very easy in combat.
  • Prayer regeneration aura : players mention auras like Harmony/Master Harmony helping them sustain longer at vyres.
  • Cremate enough vyre corpses : one guide says each vyre kill restores prayer, increasing from 1% to 5% after cremating 250 vyre corpses.
  • Prayer potions / super restores : these are the straightforward backup if your setup still drains prayer too fast.

What usually works best

If you want an AFK-friendly approach, the strongest combo is usually:

  1. Cremate vyre corpses early to build the restore bonus.
  1. Use a bonecrusher-style passive restore setup so kills feed prayer back into you.
  1. Add prayer regen support if your gear or combat style still leaves a gap.

If you are struggling

If prayer is still dropping fast, it usually means one of these is happening:

  • You have not built up the vyre cremation prayer bonus yet.
  • Your gear or aura is not giving enough sustain for your combat style.
  • You need to use regular prayer restores as a buffer while you stabilize the setup.

A simple “works for most people” setup is: cremate vyres, wear Demon horn necklace, use bonecrusher, and carry prayer pots as backup.

TL;DR: For vyres, the best prayer replenishment is usually Demon horn necklace + bonecrusher , boosted by cremating vyre corpses and optionally a prayer regen aura ; keep prayer pots as insurance.