Runeseeker’s Call in Path of Exile 2 is obtained by finishing the secret Runeseeker’s Pursuit quest: kill Uhtred, the Stardrinker to get the Depleted Mana Rune , take it to Farrow , then raise your mana to 10,000 and use the rune to turn it into the Infused Mana Rune before returning it for the unique wand.

How it works

  1. Defeat Uhtred, the Stardrinker. He drops the Depleted Mana Rune.
  1. Bring the rune to Farrow to start the secret quest.
  1. Reach 10,000 mana on your character. The guides describe this as the key requirement to activate the rune.
  1. Right-click the rune to convert it into the Infused Mana Rune.
  1. Hand it back to Farrow to receive Runeseeker’s Call.

Important notes

  • The process is built around a very high-mana setup, so many players respec heavily for it.
  • One guide says the quest and reward are one-time per character.
  • If you are trying to farm the item directly, a June 2026 guide also frames it as part of the Return of the Ancients / Runes of Aldur content cycle.

Quick answer

If you want the shortest version: beat Uhtred, get the Depleted Mana Rune, hit 10,000 mana, convert the rune, and turn it in to Farrow.

TL;DR

Runeseeker’s Call comes from a hidden quest tied to Uhtred and a 10,000-mana requirement, not from normal random drops.