Dexies (slang for dexamphetamine/Dexedrine) usually last around 4–6 hours for immediate‑release tablets and about 8–12 hours for extended‑release forms, but this can vary a lot from person to person. Even after the “buzz” or noticeable effect wears off, the drug and its effects on your body can linger for much longer.

Quick Scoop

  • Immediate‑release “dexies”
    • Onset: usually within about 30–60 minutes.
* Main effects: often felt for roughly 4–6 hours in many people.

* Some forum users report as short as 2–3 hours or up to around 6 hours, depending on dose and their body.
  • Extended‑release (XR) versions
    • Designed to release slowly over time.
    • Typical effect window is roughly 8–12 hours for many users.
  • In your system vs. how long you feel it
    • The half‑life of Dexedrine is about 12 hours, meaning it takes around that long for half of the drug to clear.
* Drug tests (urine/blood) can often pick it up for 1–2 days, and hair tests for up to about 90 days.
  • Why it feels different person to person
    • Metabolism, age, liver health, body weight, hydration, fitness, and whether you take it with food all change how long it hits and how intense it feels.
* People on ADHD forums describe anything from a short 3‑hour burst to coverage from early morning until evening with split doses or XR plus a “booster.”

A quick reality check

  • Using dexies without a prescription or mixing with alcohol/other drugs can increase risks like anxiety, heart strain, and bad comedowns.
  • If this is a prescribed med and it feels like it wears off too fast or lasts too long, prescribers can often adjust dose, timing, or formulation rather than you tweaking it on your own.

Information gathered from public forums or data available on the internet and portrayed here.