A standard 12 fl oz (355 ml) can of Dr Pepper contains about 41 mg of caffeine.

Quick Scoop

  • Regular Dr Pepper (12 oz can): ~41 mg caffeine.
  • Diet Dr Pepper (12 oz): ~41 mg caffeine (about the same as regular).
  • Dr Pepper Zero Sugar (12 oz): roughly 41–44 mg caffeine, usually listed around 44 mg on some newer labels.
  • Larger 20 oz bottle: about 68 mg caffeine.
  • Caffeine‑Free Dr Pepper (regular or diet): 0 mg caffeine.

In simple terms, a can of Dr Pepper has a moderate caffeine hit: more than Coca‑Cola (about 34 mg per 12 oz) but less than many energy drinks or a typical cup of coffee (around 80–95 mg per 8–12 oz).

If you’re watching your intake, most health guidelines suggest up to about 400 mg of caffeine per day for healthy adults, so one can of Dr Pepper uses only a small portion of that “budget.”