You can usually use saline nasal spray many times a day and even long term, because it does not contain medication and does not cause dependence or rebound congestion the way decongestant sprays do. Most adults use it anywhere from a few times per week to several times per day, depending on dryness, allergies, or colds, and this is generally considered safe if used as directed. If you find yourself needing it very frequently (for example, every hour, every day), or your congestion lasts more than about 1–2 weeks, it is important to check with a healthcare professional to make sure there is not an underlying problem that needs treatment.