The cell replicates its DNA during the S phase (Synthesis phase) of the cell cycle.

Quick Scoop

  • The eukaryotic cell cycle has four main phases: G1, S, G2, and M.
  • In G1 , the cell grows and prepares the machinery needed for DNA replication, but DNA is not yet being copied.
  • In the S phase , the actual DNA replication occurs; each chromosome is duplicated so it consists of two sister chromatids.
  • In G2 , the cell continues to grow and prepares for mitosis, but DNA replication is already finished.
  • In the M phase (mitosis), the duplicated chromosomes are separated into two daughter cells; no new DNA replication happens here.

So if you see a multiple‑choice question asking, “In which phase of the cell cycle does the cell replicate its DNA?” the correct answer is: S phase (Synthesis phase).

Meta description: Learn in which phase of the cell cycle a cell replicates its DNA, with a quick explanation of G1, S, G2, and M phases and why S phase is the DNA synthesis stage.

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