The “molecule that can self splice” is RNA , specifically certain self‑splicing introns that act as catalytic RNA (ribozymes).

What “self‑splicing” means

Some RNA molecules contain introns (non‑coding segments) that can cut themselves out and join the surrounding coding regions (exons) back together without any protein enzymes.

These special intron sequences fold into complex three‑dimensional shapes and catalyze the chemical steps of splicing on their own, which is why they are classed as ribozymes (catalytic RNA).

Types of self‑splicing RNA

  • Group I and Group II introns are the classic self‑splicing introns, able to catalyze their own excision from precursor RNA.
  • Their RNA‑only catalysis resembles the protein–RNA spliceosome and is thought to be evolutionarily related to modern splicing machinery.

Why RNA is the crossword‑style answer

A recent crossword clue “molecule that can self‑splice” is explicitly answered with the three‑letter entry RNA , reflecting the fact that RNA (via self‑splicing introns) can catalyze its own splicing.

So for a quick puzzle or quiz context, the expected answer is simply: RNA.

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