Dustin Poirier’s most notable wins are usually the ones over elite names and title-level opponents, especially Max Holloway, Conor McGregor, Justin Gaethje, and Eddie Alvarez. His biggest career-highlight victory is the 2019 win over Holloway, which earned him the interim UFC lightweight title.

Standout wins

  • Max Holloway — Poirier beat Holloway in 2019 to win the interim lightweight belt.
  • Conor McGregor — He defeated McGregor in their 2021 rematch and trilogy, giving him two of the most talked-about wins of his career.
  • Justin Gaethje — A major high-level lightweight win that boosted his title case and reputation as a durable finisher.
  • Eddie Alvarez — Another signature win over a former champion, often included among his best performances.

Why these matter

Poirier’s résumé stands out because he repeatedly beat top-tier UFC stars, not just contenders. That’s why his legacy is often framed around both big-name wins and how often he fought elite competition.

Quick note

If you want the cleanest “best wins only” shortlist, it’s usually: Holloway, McGregor twice, Gaethje, and Alvarez.