Buffout in Fallout 4 is a combat chem that temporarily boosts your physical stats, making you hit harder, tank more damage, and carry more gear at the cost of possible addiction once it wears off.

Core effects

  • Buffout gives +2 Strength , +2 Endurance , and +50 Max HP while active, letting you deal more melee damage, take more punishment, and survive longer in fights.
  • It appears as a small brown jar of pills and is classified as a chem, so it stacks with armor, perks, and food buffs.

Drawbacks and addiction

  • When Buffout wears off, there is a chance to become addicted, which applies -1 Strength and -1 Endurance until cured at a doctor or with Addictol.
  • As a chem, overuse can leave your character weaker between doses, especially noticeable for melee or tank builds that rely on those stats.

Gameplay uses

  • Great for melee or unarmed builds that want higher damage and more carry weight from the temporary Strength boost.
  • The extra Max HP is especially useful in tough boss fights, Survival mode, or when you expect to take burst damage.

Crafting and combos

  • Buffout is used to craft stronger combo chems like Bufftats and Buffjet, which mix its stat boosts with other effects for longer duration or extra bonuses.
  • These crafted variants can further raise Strength, Endurance, Perception, and Max HP, making Buffout a core ingredient in many high‑end combat chem setups.

TL;DR: Buffout in Fallout 4 is a steroid‑like chem that temporarily increases Strength, Endurance, and Max HP, making you stronger and tougher, but risks addiction that lowers those stats after it wears off.

Information gathered from public forums or data available on the internet and portrayed here.