Amyloidosis is a rare condition where an abnormal protein called amyloid builds up in tissues and organs, which can interfere with how they work. Symptoms vary depending on which organs are affected, but common signs include fatigue , weight loss , shortness of breath , and swelling in the feet, ankles, or legs.

Common symptoms

  • Feeling very tired or weak.
  • Unexplained weight loss.
  • Shortness of breath.
  • Swelling in the feet, ankles, legs, or belly.
  • Numbness, tingling, or pain in the hands or feet.
  • Easy bruising, especially around the eyes.
  • Digestive problems such as diarrhea, constipation, nausea, or loss of appetite.

Other possible signs

If amyloid affects the heart, people may notice irregular heartbeat, dizziness, chest pain, or worsening swelling. If it affects the kidneys, there may be frothy urine or fluid retention. Some people also develop a larger tongue, skin changes, or bleeding more easily.

When to get help

These symptoms are not specific to amyloidosis and can happen with many other conditions, but persistent fatigue, swelling, unexplained weight loss, or shortness of breath should be checked by a clinician. Early diagnosis matters because amyloidosis can affect several organs and become serious if it is missed.

TL;DR: Amyloidosis is a protein buildup disease, and the most common symptoms are tiredness, weight loss, swelling, shortness of breath, and nerve or digestive problems.