The Cayo Perico Heist cooldown is 48 minutes for co-op runs, and 144 minutes (2 hours 24 minutes) for solo runs. Rockstar also gives solo players a separate 72-hour window that affects primary target odds, not the basic restart timer.

How it works

  • Co-op: you can start again after 48 minutes.
  • Solo: you must wait 3 in-game days , which equals 144 minutes of real time.
  • Hard mode window: after the cooldown ends, you have 48 minutes to pay the setup fee and keep Hard Mode.

Extra note

The 72-hour period is about loot probabilities , not just replay timing. During that window, lower-value primary targets become more likely, while better targets become less common.

Quick takeaway

If you’re grinding it with friends, the cooldown is short; if you’re doing it solo, plan around the longer 2 hours 24 minutes wait.