Rough endoplasmic reticulum (RER) → Golgi apparatus → secretory vesicles → plasma membrane → outside the cell.

Quick Scoop

A newly synthesized protein that is going to be secreted follows the classical secretory pathway in a eukaryotic cell.

1. Starting point: rough ER

  • The protein is synthesized on ribosomes bound to the rough ER, guided there by an N‑terminal signal sequence.
  • As it is translated, it is threaded into the ER lumen where it begins folding and gets initial modifications (like glycosylation).

2. Next stop: Golgi apparatus

  • From the ER, the protein is packaged into transport vesicles that bud off and move to the cis face of the Golgi.
  • In the Golgi, it is further modified, sorted, and concentrated for secretion.

3. Final steps: secretory vesicle → plasma membrane → outside

  • The fully processed protein is loaded into secretory vesicles that bud from the trans-Golgi.
  • These vesicles travel to and fuse with the plasma membrane (exocytosis), releasing the protein to the extracellular space.

Put in MCQ-style order

If you see this as a multiple-choice question, the correct order is typically phrased as:

rough ER ⇒ Golgi transport vesicle ⇒ Golgi cisternae ⇒ secretory vesicle ⇒ cell surface.

Meta description (for SEO):
Learn the most likely pathway taken by a newly synthesized protein that will be secreted by a cell: from rough ER to Golgi to secretory vesicles and out through the plasma membrane, explained in a clear stepwise manner.

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