Use Protect from Missiles if you’re ranging or maging Skeletal Wyverns, and Protect from Melee if you’re fighting them up close. You also need a dragonfire-type shield, like a mind shield, elemental shield, dragonfire shield, or similar, because their icy breath still hits hard otherwise.

Practical setup

  • Melee: Protect from Melee.
  • Range/Magic: Protect from Missiles.
  • Always: Bring a proper anti-dragon/wyvern shield for the breath attack.

Small tip

If you’re safe-spotting them, the prayer usually changes based on whether you’re in their attack range, but for most players on task, Protect from Missiles is the default choice.

TL;DR: Protect from Missiles at distance, Protect from Melee in melee range, and always wear a shield against their breath.