“Grey’s Anatomy” first premiered on ABC on March 27, 2005, as a mid‑season replacement medical drama created by Shonda Rhimes.

Premiere details

  • The show debuted in the U.S. on March 27, 2005, airing after “Desperate Housewives” during ABC’s Sunday lineup.
  • It was introduced as a mid‑season replacement but quickly became a long‑running medical drama with over twenty seasons as of the mid‑2020s.

Quick scoop style recap

  • Start date to remember: March 27, 2005 – the day viewers first met Meredith Grey and the original intern class at Seattle Grace Hospital.
  • Two decades on, the series is still airing new seasons in 2025–2026, making it one of the longest‑running prime‑time medical dramas in TV history.

TL;DR: “Grey’s Anatomy” started on March 27, 2005, and has been running ever since, remaining a staple of ABC’s drama lineup.

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