The Kansas City Chiefs’ first preseason game of the 2025 season is on Saturday, August 9, 2025 , on the road against the Arizona Cardinals in Glendale, Arizona, with kickoff at 7:00 p.m. CDT (8:00 p.m. Eastern).

Since you asked “when is the first chiefs preseason game,” this Arizona matchup is the first preseason appearance for Kansas City on the 2025 schedule.