The one common body fluid that essentially has no usable DNA is the clear fluid inside the eye called the vitreous humor (often just “vitreous”).

Quick Scoop

Most human body fluids contain at least a tiny amount of DNA because they usually carry some cells (like blood cells, skin cells, or bacteria). The vitreous humor is different: it is mostly a cell‑free, gel‑like fluid, so under normal conditions it has negligible or practically zero intact DNA , which is why it is sometimes treated as “no DNA” in forensic and medical contexts.

What studies show

  • A 2023 study measuring DNA in many tissues and fluids found detectable DNA in almost everything tested , but only about 1 microgram per milliliter or less in the vitreous body, at the very bottom of their chart.
  • The same research notes that gastric juice can show “0” because any DNA present is extremely degraded , meaning it is not useful for profiling.

So, in everyday “which body fluid has no DNA?” discussions, people usually point to:

  • Vitreous humor – essentially DNA‑free in practical, forensic terms.
  • Gastric juice – may be measured as 0 because DNA is heavily destroyed, so it is not useful.

Why most fluids still have DNA

Even “watery” fluids such as:

  • Sweat
  • Tears
  • Saliva
  • Urine

can still contain small numbers of cells (skin cells, immune cells, epithelial cells) or microbial DNA, so sensitive tests can often find at least some DNA there.

Information gathered from public forums or data available on the internet and portrayed here.