The best boss to farm for Locran’s Talisman is Andariel if you want the clearest boss-targeted chance, with Harbinger of Hatred also listed as a drop source in current season loot tables. Locran’s Talisman is not an Uber Boss drop, and one source notes you can also get it from the Eyes of the Enemy questline as a guaranteed quest reward.

Best target

  • Andariel : listed as a boss that drops Locran’s Talisman.
  • Harbinger of Hatred : also listed as a boss source.
  • Not Uber Bosses : several guides say Uber Bosses do not drop it.

Fastest route

  • If you have not done the quest, complete Eyes of the Enemy in World Tier 3 or 4 for a guaranteed copy.
  • If you are farming for extra drops or better rolls, target Andariel first based on the boss loot-table sources currently cited.
  • General farming in Infernal Hordes , World Bosses, Nightmare Dungeons, and Gathering Legions can also help, but those are broader drop pools rather than the best single-boss target.

Practical pick

For pure boss farming, Andariel is the best bet from the sources I found. If your goal is just to get the item once, the quest reward is the most reliable path.