The part of the enzyme that binds with the substrate is the active site.

Quick Scoop

  • The active site is a small, specially shaped region on the enzyme where the substrate fits and attaches.
  • It is made of specific amino acid residues that create a unique 3D shape and chemical environment so that only particular substrates can bind, like a key fitting into a lock.
  • When the substrate binds to the active site, they form an enzyme–substrate complex, which allows the enzyme to speed up the reaction.

In exam-style multiple-choice questions, when they ask “Which part of the enzyme binds with the substrate?”, the correct answer is: Active site.

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