Purdue lost as a No. 1 seed to Fairleigh Dickinson in the 2023 NCAA Tournament , a first-round upset that ended 63-58.

Other notable No. 1-seed losses

  • Purdue also lost as a No. 1 seed to Houston in 2025 , falling 62-60 in the Sweet 16.
  • In its earlier history against No. 1 seeds, Purdue lost to Kansas in 1997 as a No. 8 seed, not as a No. 1 seed.

Quick context

That Fairleigh Dickinson loss is the one most people mean when they ask this question, because it was one of the biggest March Madness upsets ever.

YearOpponentSeedResult
2023Fairleigh DickinsonNo. 16Purdue lost 63-58
2025HoustonNo. 1Purdue lost 62-60
TL;DR: Purdue’s famous No. 1-seed loss was to **Fairleigh Dickinson** in 2023.