The San Francisco 49ers’ notable loss this season was against the Jacksonville Jaguars, 26–21, in a home game at Levi’s Stadium.

Key Loss This Season

  • The 49ers lost 26–21 to the Jacksonville Jaguars in Week 4 of the 2025 regular season.
  • It was their first loss to the Jaguars since 2005 and also their first-ever home loss to Jacksonville.

Game context

  • The Jaguars broke the game open with big plays, including a long touchdown run by Travis Etienne Jr. and an 87-yard punt return touchdown by Parker Washington.
  • Brock Purdy threw for over 300 yards and two touchdowns, but turnovers and special-teams mistakes proved too costly for San Francisco.

Bottom note: Information gathered from public forums or data available on the internet and portrayed here.