50 Cent has had public beef or ongoing spats with a long list of rappers, producers, and celebrities over the years, but the most prominent names right now are:

  • Sean “Diddy” Combs
  • Ja Rule
  • The Game
  • Rick Ross
  • Fat Joe
  • Marlon Wayans
  • Jay‑Z (more of a trolling/roasting dynamic than a full‑blown street feud)

Biggest ongoing beef

Diddy (Sean Combs)

This is currently the most high‑profile conflict. 50 Cent reignited their long‑running rivalry by producing a Netflix documentary about Diddy in 2025 that aired around the time of Combs’ arrest and related lawsuits.

50 has repeatedly accused Diddy of shady behavior, including implying involvement in Biggie’s murder and criticizing his party culture, while Diddy and allies have pushed back online and in interviews.

Ja Rule

One of hip‑hop’s most famous rap feuds. 50 and Ja Rule have been trading insults and diss tracks since the early 2000s, with 50 often mocking Ja Rule’s career and image on social media.

Though the tension has cooled at times, 50 still roasts Ja Rule online , keeping the beef simmering rather than fully dead.

The Game

50 and The Game were once close (Game was in G‑Unit), but their fallout turned into one of the messiest rap rivalries of the 2000s, with public diss tracks and even reports of real‑life confrontations.

They’ve had brief reconciliations, but 50 still occasionally calls out The Game on social media, so the history of tension remains relevant.

Other notable names he’s beefed with

  • Rick Ross – 50 has trolled Ross over ticket‑sales jokes and other career‑related digs in recent years.
  • Fat Joe – Old‑school East Coast rivalry; 50 has dissed Joe in songs and online, and Joe has fired back.
  • Marlon Wayans – Beef flared in 2025 after Wayans defended Diddy and 50 clapped back with Instagram posts mocking him.
  • Jay‑Z – Less of a classic “rap war,” more of 50 randomly taking shots at Jay‑Z when he’s in the news, especially around Diddy‑related controversies.

Quick reference table

Person / group| Type of beef with 50 Cent| Current status (2026)
---|---|---
Sean “Diddy” Combs| Long‑running feud, revived by Diddy doc & legal drama 159| Very active / public
Ja Rule| Classic rap rivalry, diss tracks & online roasts 610| Mostly online, still simmering
The Game| Former G‑Unit member turned rival, real‑life drama 46| Occasional call‑outs
Rick Ross| Social‑media trolling over career & sales 26| Light‑to‑moderate
Fat Joe| East‑Coast‑style rivalry, past diss tracks 36| Mostly legacy, some online shots
Marlon Wayans| Spat over Diddy doc & comments on 50’s actions 59| Recent, social‑media‑driven
Jay‑Z| 50 takes random shots, not a full‑scale war 27| Occasional trolling

If you tell me which beef you care about most (Diddy, Ja Rule, The Game, etc.), I can break down the timeline and key moments in more detail.