Izzie Stevens ultimately ends up with Alex Karev on Grey’s Anatomy.

Quick Scoop: Who does Izzie end up with?

  • Izzie’s major romances include Denny Duquette, George O’Malley, and Alex Karev.
  • She actually marries Alex Karev during her cancer storyline at Seattle Grace.
  • After she leaves the hospital and sends Alex divorce papers, her story seems over for a while.
  • In a later twist revealed in a 2020 episode, Alex leaves Seattle to reunite with Izzie and their twins, giving them a long-distance happy ending together.

In other words: even after all the breakups and drama, the show’s late-game letters reveal that Izzie and Alex are the ones who end up together in the end.

TL;DR: Izzie ends up with Alex Karev; they build a life together with their kids off-screen, confirmed in a later Grey’s Anatomy episode.

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