DNA makes a copy of itself during the S phase (Synthesis phase) of interphase in the cell cycle.

Quick Scoop

  • DNA replication happens before a cell divides so that each new cell gets a complete set of genetic instructions.
  • In eukaryotic cells, this copying occurs specifically in the S phase of interphase, between G1 and G2 phases.
  • By the end of S phase, every chromosome has been duplicated into two identical sister chromatids, still joined together.

So if a test asks “During which phase does the DNA make a copy of itself?”, the best answer is: S phase of interphase.

Meta description: Learn during which phase DNA makes a copy of itself, why this happens in S phase of interphase, and how it fits into the cell cycle, explained simply for quick study.

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