DNA is duplicated during the S phase (Synthesis phase) of interphase in the cell cycle.

Quick Scoop

  • The cell cycle has two main broad parts: interphase and mitosis (M phase).
  • Interphase is subdivided into G1, S, and G2 phases.
  • During S phase, the cell replicates its DNA so that each chromosome is copied into two sister chromatids, ensuring each daughter cell can receive a full genome at division.

So, when you see the question “during which phase is the DNA duplicated?”, the precise answer is: S phase of interphase.