One average slice of pizza usually has about 200–400 calories , depending a lot on size, crust, and toppings.

Quick Scoop

For a typical, regular slice (about 1/8 of a medium 12–14 inch pizza):

  • Plain cheese slice: roughly 250–300 calories.
  • Pepperoni slice: often 300–450 calories , since meat and extra cheese add fat.
  • Deep-dish or stuffed crust: can easily exceed 400–500 calories per slice.
  • Lighter thin-crust veggie slice: can be closer to 200–250 calories if the slice is smaller and toppings are mostly vegetables.

As a concrete example, one guide lists an average slice at about 285 calories , with roughly 10 g fat, 36 g carbs, and 12 g protein. Another nutrition sheet shows a slice of pepperoni pizza (1/8 of a 12-inch) at around 240–253 calories , depending on recipe.

So if you just need a fast rule of thumb for “how many calories in one slice of pizza,” a realistic estimate is:

Plan for ~250–350 calories per standard slice, higher if it’s big, cheesy, or deep-dish.

Information gathered from public forums or data available on the internet and portrayed here.