In Roblox Studio, you can remove or change a shortcut by going to File > Keybinds and searching for the action you want to turn off, then clearing that binding. For Studio shortcuts that still trigger while a game is running, go to File > Settings > Studio and uncheck “Respect Studio shortcuts when game has focus.”

Quick fix

  • Open File > Keybinds.
  • Search for the shortcut you want to disable.
  • Clear it or reassign it to another key.

If it happens in Play mode

  • Open File > Settings.
  • Go to Studio.
  • Turn off Respect Studio shortcuts when game has focus.

Note

If you meant in-game keybinds from your own Roblox script rather than Studio shortcuts, those are usually handled in code by unbinding the action or disconnecting the input event.

If you want, I can also show the exact steps for disabling a specific Roblox Studio shortcut like Move, Scale, or Delete.