“Best Medicine” is a new Fox medical dramedy that films in upstate New York, mainly around the Hudson Valley and Cornwall, but the story itself is set in a fictional quaint East Coast fishing village. So the on-screen town you see is made-up, while the real shooting locations are places like Newburgh, New Hamburg, and Cornwall in New York.

Quick Scoop

  • The series is a medical dramedy about a surgeon who returns to his childhood hometown, causing friction with locals.
  • Production has been spotted filming in several Hudson Valley spots, including near the New Hamburg Yacht Club and studio spaces in Newburgh.
  • Cornwall, New York (including Angola Road) has also been used as a backdrop, with local streets temporarily turned into TV sets.
  • Within the show’s fiction, the town is described as a “quaint East Coast fishing village,” blending small-town coastal vibes with medical-hospital storylines.

Where it “takes place” vs. where it’s filmed

  • In the story: A small, tight‑knit East Coast fishing village that functions as the doctor’s hometown and primary setting for the hospital/clinic and town drama.
  • In real life:
    • Hudson Valley, New York (including Newburgh and nearby riverfront areas).
* Cornwall, NY, where residential streets and local homes have doubled as locations.

So if you’re asking “where does Best Medicine take place,” the fictional answer is a coastal East Coast village, but the practical, behind‑the‑scenes answer is upstate New York in the Hudson Valley and Cornwall.

TL;DR: Best Medicine is set in a fictional East Coast fishing village but is filmed around upstate New York’s Hudson Valley, especially Newburgh, New Hamburg, and Cornwall.

Information gathered from public forums or data available on the internet and portrayed here.