The most recent game that ended the Indianapolis Colts’ season was a loss to the Houston Texans , 38–30, in Week 18 of the 2025 NFL season.

Latest Colts loss

  • The Colts closed the 2025 regular season with a road defeat against the Houston Texans by a score of 38–30, finishing with an 8–9 record.
  • That Week 18 loss officially eliminated them from playoff contention and marked the seventh straight defeat to end a season that once stood at 7–1.

If you meant a different game

  • If the question is about a specific week (for example, “Who did the Colts lose to last week?” during the season), the answer would depend on the exact date and week you have in mind.
  • Right now, the clearest “latest loss” on record for them is that Week 18 38–30 defeat to the Texans that ended their 2025 campaign.

Information gathered from public forums or data available on the internet and portrayed here.