A typical slice of pepperoni pizza has roughly 300–350 calories, with many “standard” large-slice estimates clustering around about 300–320 calories per slice.

Quick Scoop

  • A common estimate for one slice of hand‑tossed pepperoni from a large 14‑inch pizza is about 311 calories.
  • Many general nutrition guides give a range of about 300–350 calories for an average slice of pepperoni pizza.
  • Thin crust slices tend to be closer to 250–300 calories, while thick or deep‑dish pepperoni slices can reach 350–400+ calories.

What Changes the Calorie Count?

Key factors that change “how many calories in a slice of pepperoni pizza”:

  • Crust type : Thin crust uses less dough (fewer carbs and calories) than regular or deep‑dish crust.
  • Slice size : Nutrition info usually assumes 1 slice = 1/8 of a 12–14 inch pizza; jumbo or NYC slices can be significantly higher.
  • Cheese and pepperoni amount : Extra cheese or “extra pepperoni” quickly increases fat, sodium, and total calories.
  • Brand/restaurant : Chains and frozen pizzas can vary a lot, so checking the nutrition info on the box or restaurant site gives the most accurate number.

Simple Rule of Thumb

If you don’t have a label or app handy, this rough guide works for most situations:

  • Thin crust pepperoni slice: ~250–300 calories.
  • Regular/hand‑tossed pepperoni slice: ~300–330 calories.
  • Thick crust or deep‑dish pepperoni slice: ~350–400 calories or more.

So if you’re logging food or just sanity‑checking a meal, estimating 300–350 calories for a normal pepperoni slice is usually a reasonable approximation. Information gathered from public forums or data available on the internet and portrayed here.