Mewtwo is weak to three main types: Bug, Ghost, and Dark attacks.

Quick Scoop

  • Mewtwo is a pure Psychic-type Pokémon, so its classic weaknesses are:
    • Bug-type moves.
* Ghost-type moves.

* Dark-type moves.
  • It resists Fighting and Psychic moves, so avoid using those against it.

Example counters

  • Dark-types like Tyranitar or Hydreigon using Dark STAB moves.
  • Ghost-types like Gengar with strong Ghost attacks.
  • Bug-type attackers such as Scizor with Bug moves.

In most modern games and Pokémon GO, if you remember “Bug, Ghost, Dark beat Mewtwo,” you’ll be in good shape.

TL;DR: If you’re asking what is Mewtwo weak to , hit it with Bug, Ghost, or Dark-type moves and avoid Fighting and Psychic.

Information gathered from public forums or data available on the internet and portrayed here.